General Information

General Information

DRAVP ID DRAVPe00355

Peptide Name Caerin-1.6

Sequence GLFSVLGAVAKHVLPHVVPVIAEKL

Sequence Length 25

UniProt ID P62546 P56231 P81249 P62547

Source Litoria xanthomera (Orange-thighed frog) (Litoria chloris)

Activity Information

Target Organism HIV

Assay

Activity

[Ref.26026377]HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.26026377]Human endocervical cells End1/E6E7:50% cell death at 10 µM.

Binding Target membrane

Mechanism The peptide could disrupt the viral envelope and release p24 protein.And the more effective they were at disruption of the viral envelope, the better they were at inhibiting infection.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00355

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C124H205N31O29

Absent amino acids CDMNQRTWY

Common amino acids V

Mass 2594.18

Pl 8.61

Basic residues 4

Acidic residues 1

Hydrophobic residues 15

Net charge 3

Boman Index 2850

Hydrophobicity 122.4

Aliphatic Index 159.6

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 3

Literature Information

Literature 1

Title Inhibition of HIV infection by caerin 1 antimicrobial peptides.

Pubmed ID 26026377

Reference Peptides. 2015 Sep;71:296-303.

Author VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

DOI 10.1016/j.peptides.2015.05.004