General Information

General Information

DRAVP ID DRAVPe00360

Peptide Name Caerin-1.5

Sequence GLLSVLGSVVKHVIPHVVPVIAEHL

Sequence Length 25

UniProt ID P56230

Source Litoria caerulea (Green tree frog)

Activity Information

Target Organism HIV

Assay

Activity

[Ref.26026377]HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=3 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.26026377]Human endocervical cells End1/E6E7:50% cell death at 12.5 µM.

Binding Target membrane

Mechanism The peptide could disrupt the viral envelope and release p24 protein.And the more effective they were at disruption of the viral envelope, the better they were at inhibiting infection.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00360

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C123H206N32O30

Absent amino acids CDFMNQRTWY

Common amino acids V

Mass 2613.19

Pl 7.02

Basic residues 4

Acidic residues 1

Hydrophobic residues 14

Net charge 3

Boman Index 2835

Hydrophobicity 131.2

Aliphatic Index 178.8

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 4

Literature Information

Literature 1

Title Inhibition of HIV infection by caerin 1 antimicrobial peptides.

Pubmed ID 26026377

Reference Peptides. 2015 Sep;71:296-303.

Author VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

DOI 10.1016/j.peptides.2015.05.004