To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00361
Peptide Name Caerin 1.1 mod 7(Caerin 1.1 [E23A,H24A])
Sequence GLLSVLGSVAKHVLPHVVPVIAAAL
Sequence Length 25
UniProt ID No entry found
Source Sythetic construct(derived from Caerin 1.1)
Activity Information
Target Organism HIV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target virion envelope
Mechanism [Ref.26026377]Inhibit the infection of HIV by disrupting the HIV envelope and release viral core protein (p24).
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00361
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C116H198N30O28
Absent amino acids CDEFMNQRTWY
Common amino acids V
Mass 2461.03
Pl 8.76
Basic residues 3
Acidic residues 0
Hydrophobic residues 16
Net charge 3
Boman Index 4121
Hydrophobicity 160
Aliphatic Index 179.2
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Literature Information
Literature 1
Title VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.
Pubmed ID 26026377
Reference Peptides. 2015 Sep;71:296-303.
Author Inhibition of HIV infection by caerin 1 antimicrobial peptides.
DOI 10.1016/j.peptides.2015.05.004
Literature 2
Title Rollins-Smith LA, Smith PB, Ledeczi AM, Rowe JM, Reinert LK.
Pubmed ID 33008028
Reference Antibiotics (Basel). 2020 Sep 30;9(10):661.
Author Caerin 1 Antimicrobial Peptides That Inhibit HIV and Neisseria May Spare Protective Lactobacilli.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.