General Information

General Information

DRAVP ID DRAVPe00365

Peptide Name Caerin 1.20

Sequence GLFGILGSVAKHVLPHVIPVVAEHL

Sequence Length 25

UniProt ID No entry found

Source Litoria caerulea/Litoria splendida

Activity Information

Target Organism HIV

Assay

Activity

[Ref.26026377]Human immunodeficiency virus (HIV): inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=7 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.26026377]CD4+ T Lymphocytes:50% cell death at 25 µM;Human endocervical cells End1/E6E7:50% cell death at 22 µM.

Binding Target virion envelope

Mechanism [Ref.26026377]Inhibit the infection of HIV by disrupting the HIV envelope and release viral core protein (p24).

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00365

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C124H200N32O29

Absent amino acids CDMNQRTWY

Common amino acids V

Mass 2603.15

Pl 7.02

Basic residues 4

Acidic residues 1

Hydrophobic residues 14

Net charge 3

Boman Index 2940

Hydrophobicity 117.6

Aliphatic Index 159.6

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 4

Literature Information

Literature 1

Title VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

Pubmed ID 26026377

Reference Peptides. 2015 Sep;71:296-303.

Author Inhibition of HIV infection by caerin 1 antimicrobial peptides.

DOI 10.1016/j.peptides.2015.05.004

Literature 2

Title Rollins-Smith LA, Smith PB, Ledeczi AM, Rowe JM, Reinert LK.

Pubmed ID 33008028

Reference Antibiotics (Basel). 2020 Sep 30;9(10):661.

Author Caerin 1 Antimicrobial Peptides That Inhibit HIV and Neisseria May Spare Protective Lactobacilli.

DOI 10.3390/antibiotics9100661