General Information

General Information

DRAVP ID DRAVPe00366

Peptide Name Ctry2459-WT (Ctry2459, scorpions,animals)

Sequence FLGFLKNLF

Sequence Length 9

UniProt ID P0DMF3

Source Chaerilus tryznai (Scorpion)

Activity Information

Target Organism HCV

Assay

Activity

[Ref.23415044]Hepatitis C virus:inhibition of infection with HCV in Huh 7.5.1 cells (EC50=1.84 μg/ml).

Hemolytic Activity

[Ref.23415044] HC50 = 137.9 μg/ml against human red blood cells.

Cytotoxicity

[Ref.23415044] CC50=79.8 μg/ml against Huh7.5.1 cells.

Binding Target Not found

Mechanism The peptide potently destabilizes the viral structural integrity, thus reducing the initiation of HCV infection

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00366

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C57H83N11O11

Absent amino acids ACDEHIMPQRSTVWY

Common amino acids FL

Mass 1098.35

Pl 8.75

Basic residues 1

Acidic residues 0

Hydrophobic residues 6

Net charge 1

Boman Index 1245

Hydrophobicity 133.33

Aliphatic Index 130

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Literature Information

Literature 1

Title Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.

Pubmed ID 23415044

Reference Biomaterials. 2013 Apr;34(13):3511-22.

Author Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.

DOI 10.1016/j.biomaterials.2013.01.075