General Information


DRAVP ID  DRAVPe00366

Peptide Name   Ctry2459-WT (Ctry2459, scorpions,animals)

Sequence  FLGFLKNLF

Sequence Length  9

UniProt ID  P0DMF3 

Source  Chaerilus tryznai (Scorpion)



Activity Information


Target Organism  HCV

Assay 

Activity 

  • [Ref.23415044]Hepatitis C virus:inhibition of infection with HCV in Huh 7.5.1 cells (EC50=1.84 μg/ml).

Hemolytic Activity 

  • [Ref.23415044] HC50 = 137.9 μg/ml against human red blood cells.

Cytotoxicity 

  • [Ref.23415044] CC50=79.8 μg/ml against Huh7.5.1 cells.

Binding Target  Not found

Mechanism  The peptide potently destabilizes the viral structural integrity, thus reducing the initiation of HCV infection



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00366

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C57H83N11O11

Absent amino acids  ACDEHIMPQRSTVWY

Common amino acids  FL

Mass  1098.35

Pl  8.75

Basic residues  1

Acidic residues  0

Hydrophobic residues  6

Net charge  1

Boman Index  1245

Hydrophobicity  133.33

Aliphatic Index  130

Half Life 

  •     Mammalian:1.1 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2



Literature Information


Literature 1

Title   Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.

Pubmed ID   23415044

Reference   Biomaterials. 2013 Apr;34(13):3511-22.

Author   Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z.

DOI   10.1016/j.biomaterials.2013.01.075