DRAVP ID  DRAVPe00373

Peptide Name   Piscidin 3 (fish)

Sequence  FIHHIFRGIVHAGRSIGRFLTG

Sequence Length  22

UniProt ID  No entry found

Taxon ID  None

Source  Morone saxatilis

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HIV,CCV,FV3

Assay 

Activity 

• [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=2.1 μM).
• [Ref.15193922]Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(reduce viral infectivity by 50% at 11 μM);
• Frog Virus 3(FV3): inhibition of FV3 infection in fathead minnow(FHM) cells(reduce viral infectivity by 50% at 16 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.20086159]CEM-SS cells:50% Cell death at 6.9 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  2jos 

Predicted Structure Download  DRAVPe00373

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09

Literature 2

Title   Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides.

Pubmed ID   15193922

Reference   Virology. 2004 Jun 1;323(2):268-75.

Author   Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L.

DOI   10.1016/j.virol.2004.02.029