DRAVP ID  DRAVPe00373

Peptide Name   Piscidin 3 (fish)

Sequence  FIHHIFRGIVHAGRSIGRFLTG

Sequence Length  22

UniProt ID  No entry found

Source  Morone saxatilis

Target Organism  HIV,CCV,FV3

Assay 

Activity 

• [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=2.1 μM).
• [Ref.15193922]Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(reduce viral infectivity by 50% at 11 μM);
• Frog Virus 3(FV3): inhibition of FV3 infection in fathead minnow(FHM) cells(reduce viral infectivity by 50% at 16 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.20086159]CEM-SS cells:50% Cell death at 6.9 µM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  2jos 

Predicted Structure Download  DRAVPe00373

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

Pubmed ID   20086159

Reference   Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

Author   Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.

DOI   10.1128/AAC.01448-09

Literature 2

Title   Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides.

Pubmed ID   15193922

Reference   Virology. 2004 Jun 1;323(2):268-75.

Author   Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L.

DOI   10.1016/j.virol.2004.02.029