General Information
DRAVP ID DRAVPe00395
Peptide Name Pentadecanoic-Temporin L[Pro3,DLeu9,Nle10](TL6.7)
Sequence FVPWFSKFlXRIL
Sequence Length 13
UniProt ID No entry found
Source Synthetic construct(derived from Temporin-L)
Activity Information
Target Organism SARS-CoV-2,HSV, MeV,H1N1
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism TL peptides may be able to selectively induce pore formation in highly curved membrane structures (below ~250 nm in diameter), resulting in membrane lysis once a critical number of pores is formed, with the consequence of viral infectivity reduction.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Pentadecanoic acid
C-terminal Modification Amidation
Other Modification The 'X' at position 10 is norleucine.
Stereochemistry Mixed(D-Leu9)
Physicochemical Information
Formula C75H102N16O11
Absent amino acids ACDEGHMNQTY
Common amino acids F
Mass 1664.26
Pl 11
Basic residues 2
Acidic residues 0
Hydrophobic residues 7
Net charge 2
Boman Index 128
Hydrophobicity 70.77
Aliphatic Index 82.31
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 458.33
Polar residues 1
Literature Information
Literature 1
Title Broad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs.
Pubmed ID 35216177
Reference Int J Mol Sci. 2022 Feb 13;23(4):2060.
Author Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M.