General Information

General Information

DRAVP ID DRAVPe00397

Peptide Name Dermaseptin S4 (5-28)

Sequence TLLKKVLKAAAKAALNAVLVGANA

Sequence Length 24

UniProt ID No entry found

Source Synthetic construct(derived from Dermaseptin S4)

Activity Information

Target Organism HSV

Assay

Activity

[Ref.23161023]HSV-2 acyclovir-sensitive strain(911411):inhibition the cytopathic effect(CPE) of HSV-2 in Vero cells(EC50=27.07 μM);
HSV-2 acyclovir-resistant strain(ROI2):inhibition of cytopathic effet(CPE) of HSV-2 in Vero cells(EC50=25.27 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.23161023]Vero cells:CC50=34 μM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00397

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C107H194N30O28

Absent amino acids CDEFHIMPQRSWY

Common amino acids A

Mass 2348.9

Pl 10.48

Basic residues 4

Acidic residues 0

Hydrophobic residues 16

Net charge 4

Boman Index 1409

Hydrophobicity 92.92

Aliphatic Index 150.83

Half Life

Mammalian:7.2 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 4

Literature Information

Literature 1

Title In vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2.

Pubmed ID 23161023

Reference J Med Virol. 2013 Feb;85(2):272-81.

Author Bergaoui I, Zairi A, Tangy F, Aouni M, Selmi B, Hani K.

DOI 10.1002/jmv.23450