General Information

General Information

DRAVP ID DRAVPe00397

Peptide Name Dermaseptin S4 (5-28)

Sequence TLLKKVLKAAAKAALNAVLVGANA

Sequence Length 24

UniProt ID No entry found

Taxon ID None

Source Synthetic construct(derived from Dermaseptin S4)

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HSV

Assay

Activity

[Ref.23161023]HSV-2 acyclovir-sensitive strain(911411):inhibition the cytopathic effect(CPE) of HSV-2 in Vero cells(EC50=27.07 μM);
HSV-2 acyclovir-resistant strain(ROI2):inhibition of cytopathic effet(CPE) of HSV-2 in Vero cells(EC50=25.27 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.23161023]Vero cells:CC50=34 μM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00397

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C107H194N30O28

Absent amino acids CDEFHIMPQRSWY

Common amino acids A

Mass 2348.9

Pl 10.48

Basic residues 4

Acidic residues 0

Hydrophobic residues 16

Net charge 4

Boman Index 1409

Hydrophobicity 92.92

Aliphatic Index 150.83

Half Life

Mammalian:7.2 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 4

Literature Information

Literature 1

Title In vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2.

Pubmed ID 23161023

Reference J Med Virol. 2013 Feb;85(2):272-81.

Author Bergaoui I, Zairi A, Tangy F, Aouni M, Selmi B, Hani K.

DOI 10.1002/jmv.23450