To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00452
Peptide Name M2 AH
Sequence RLFFKCIYRFFEHGLKRG
Sequence Length 18
UniProt ID No entry found
Source Synthetic construct(derived from influenza virus M2 protein)
Activity Information
Target Organism H1N1
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism M2 AH is an α-helical amphipathic peptide with basic amino acids positioned at the polar-nonpolar interface. The peptide inserts deeply into the hydrophobic core of the membrane bilayer, resulting in alteration of membrane order and curvature . This ability to alter membrane curvature enables M2 AH to induce membrane budding in vitro and in vivo. It localizes to the neck of the budding virion and plays an important role in membrane scission.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00452
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C111H165N31O22S
Absent amino acids ADMNPQSTVW
Common amino acids F
Mass 2317.79
Pl 10.3
Basic residues 6
Acidic residues 1
Hydrophobic residues 7
Net charge 5
Boman Index -3763
Hydrophobicity -23.89
Aliphatic Index 65
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 87.65
Polar residues 4
Literature Information
Literature 1
Title Envelope-deforming antiviral peptide derived from influenza virus M2 protein.
Pubmed ID 31375212
Reference Biochem Biophys Res Commun. 2019 Sep 24;517(3):507-512.
Author Jung Y, Kong B, Moon S, Yu SH, Chung J, Ban C, Chung WJ, Kim SG, Kweon DH.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.