DRAVP ID  DRAVPe00452

Peptide Name   M2 AH

Sequence  RLFFKCIYRFFEHGLKRG

Sequence Length  18

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct(derived from influenza virus M2 protein)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  H1N1

Assay 

Activity 

• [Ref.31375212]H1N1(A/Puerto Rico/8/34):inhibition of infection in Madin-Darby canine kidney epithelial(MDCK) cells(IC50=870 nM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.31375212]Madin-Darby canine kidney epithelial(MDCK) cells:CC50=70.3 μM

Binding Target  membrane

Mechanism  M2 AH is an α-helical amphipathic peptide with basic amino acids positioned at the polar-nonpolar interface. The peptide inserts deeply into the hydrophobic core of the membrane bilayer, resulting in alteration of membrane order and curvature . This ability to alter membrane curvature enables M2 AH to induce membrane budding in vitro and in vivo. It localizes to the neck of the budding virion and plays an important role in membrane scission.

PDB ID  None

Predicted Structure Download  DRAVPe00452

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Envelope-deforming antiviral peptide derived from influenza virus M2 protein.

Pubmed ID   31375212

Reference   Biochem Biophys Res Commun. 2019 Sep 24;517(3):507-512.

Author   Jung Y, Kong B, Moon S, Yu SH, Chung J, Ban C, Chung WJ, Kim SG, Kweon DH. 

DOI   10.1016/j.bbrc.2019.07.088