General Information
DRAVP ID DRAVPe00453
Peptide Name M2 MH
Sequence RKFFKKIYRFFRKLLKRL
Sequence Length 18
UniProt ID No entry found
Source Synthetic construct(derived from influenza virus M2 protein)
Activity Information
Target Organism Influenza virus
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism M2 MH is an α-helical amphipathic peptide with basic amino acids positioned at the polar-nonpolar interface. The peptide inserts deeply into the hydrophobic core of the membrane bilayer, resulting in alteration of membrane order and curvature . This ability to alter membrane curvature enables M2 MH to induce membrane budding in vitro and in vivo. It localizes to the neck of the budding virion and plays an important role in membrane scission.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00453
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C123H199N35O20
Absent amino acids ACDEGHMNPQSTVW
Common amino acids K
Mass 2488.16
Pl 12.02
Basic residues 9
Acidic residues 0
Hydrophobic residues 8
Net charge 9
Boman Index -5597
Hydrophobicity -65
Aliphatic Index 86.67
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 87.65
Polar residues 1
Literature Information
Literature 1
Title Envelope-deforming antiviral peptide derived from influenza virus M2 protein.
Pubmed ID 31375212
Reference Biochem Biophys Res Commun. 2019 Sep 24;517(3):507-512.
Author Jung Y, Kong B, Moon S, Yu SH, Chung J, Ban C, Chung WJ, Kim SG, Kweon DH.