To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00454
Peptide Name M2 NH
Sequence RLAAKCAARFAEHGLKRG
Sequence Length 18
UniProt ID No entry found
Source Synthetic construct(derived from influenza virus M2 protein)
Activity Information
Target Organism H1N1
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism M2 NH is an α-helical amphipathic peptide with basic amino acids positioned at the polar-nonpolar interface. The peptide inserts deeply into the hydrophobic core of the membrane bilayer, resulting in alteration of membrane order and curvature . This ability to alter membrane curvature enables M2 NH to induce membrane budding in vitro and in vivo. It localizes to the neck of the budding virion and plays an important role in membrane scission.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00454
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C84H143N31O21S
Absent amino acids DIMNPQSTVWY
Common amino acids A
Mass 1955.31
Pl 10.92
Basic residues 6
Acidic residues 1
Hydrophobic residues 8
Net charge 5
Boman Index -4230
Hydrophobicity -38.33
Aliphatic Index 71.11
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Literature Information
Literature 1
Title Envelope-deforming antiviral peptide derived from influenza virus M2 protein.
Pubmed ID 31375212
Reference Biochem Biophys Res Commun. 2019 Sep 24;517(3):507-512.
Author Jung Y, Kong B, Moon S, Yu SH, Chung J, Ban C, Chung WJ, Kim SG, Kweon DH.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.