DRAVP ID  DRAVPe00456

Peptide Name   Hs-1

Sequence  FLPLILPSIVTALSSFLKQG

Sequence Length  20

UniProt ID  No entry found

Taxon ID  None

Source  Hypsiboas semilineatus

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  DENV

Assay 

Activity 

• [Ref.29153860]DENV2:reduced the number of lysis plaques by 100% at 125 µg/mL; by 60% at 7.81 μg/mL;
• DENV3:reduced the number of lysis plaques by 100% at 125 µg/mL; by 50% at 7.81 μg/mL

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.29153860]No significant cytotoxicity agaisnt Vero cells up to 125μg/ mL.

Binding Target  envelope

Mechanism  It was possible to observe that the viral particle lost its ability to infect because of the breakdown on the envelope as the peptide acted directly on the virus.

PDB ID  None

Predicted Structure Download  DRAVPe00456

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   The antimicrobial peptide HS-1 inhibits dengue virus infection.

Pubmed ID   29153860

Reference   Virology. 2018 Jan 15;514:79-87.

Author   Monteiro JMC, Oliveira MD, Dias RS, Nacif-Marçal L, Feio RN, Ferreira SO, Oliveira LL, Silva CC, Paula SO.

DOI   10.1016/j.virol.2017.11.009