General Information
DRAVP ID DRAVPe00456
Peptide Name Hs-1
Sequence FLPLILPSIVTALSSFLKQG
Sequence Length 20
UniProt ID No entry found
Source Hypsiboas semilineatus
Activity Information
Target Organism DENV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target envelope
Mechanism It was possible to observe that the viral particle lost its ability to infect because of the breakdown on the envelope as the peptide acted directly on the virus.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00456
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C104H170N22O26
Absent amino acids CDEHMNRWY
Common amino acids L
Mass 2144.63
Pl 8.75
Basic residues 1
Acidic residues 0
Hydrophobic residues 11
Net charge 1
Boman Index 2333
Hydrophobicity 127.5
Aliphatic Index 156
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Literature Information
Literature 1
Title The antimicrobial peptide HS-1 inhibits dengue virus infection.
Pubmed ID 29153860
Reference Virology. 2018 Jan 15;514:79-87.
Author Monteiro JMC, Oliveira MD, Dias RS, Nacif-Marçal L, Feio RN, Ferreira SO, Oliveira LL, Silva CC, Paula SO.