General Information

General Information

DRAVP ID DRAVPe00457

Peptide Name gg-ww

Sequence GGARDAGKAEWW

Sequence Length 12

UniProt ID No entry found

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism DENV

Assay

Activity

[Ref.26248692]dengue virus serotype 2(DENV-2):inhibition the cytopathic effect(CPE) and plaque formation in Vero cells(IC50=77-91 μmol/L).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.26248692]It was not toxic to Vero cells up to 400 μmol/L.

Binding Target membrane

Mechanism The peptide gg-ww could exert its inhibition during the viral entry step of DENV-2 infection by interfering with viral attachment or internalization.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00457

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C58H82N18O17

Absent amino acids CFHILMNPQSTVY

Common amino acids AG

Mass 1303.4

Pl 6.07

Basic residues 2

Acidic residues 2

Hydrophobic residues 5

Net charge 0

Boman Index -2309

Hydrophobicity -108.33

Aliphatic Index 25

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 11000

Absorbance 280nm 1000

Polar residues 3

Literature Information

Literature 1

Title Anti-dengue virus serotype 2 activity and mode of action of a novel peptide.

Pubmed ID 26248692

Reference J Appl Microbiol. 2015 Oct;119(4):1170-80.

Author Chew MF, Tham HW, Rajik M, Sharifah SH.

DOI 10.1111/jam.12921