General Information

General Information

DRAVP ID DRAVPe00457

Peptide Name gg-ww

Sequence GGARDAGKAEWW

Sequence Length 12

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism DENV

Assay

Activity

[Ref.26248692]dengue virus serotype 2(DENV-2):inhibition the cytopathic effect(CPE) and plaque formation in Vero cells(IC50=77-91 μmol/L).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.26248692]It was not toxic to Vero cells up to 400 μmol/L.

Binding Target membrane

Mechanism The peptide gg-ww could exert its inhibition during the viral entry step of DENV-2 infection by interfering with viral attachment or internalization.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00457

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C58H82N18O17

Absent amino acids CFHILMNPQSTVY

Common amino acids AG

Mass 1303.4

Pl 6.07

Basic residues 2

Acidic residues 2

Hydrophobic residues 5

Net charge 0

Boman Index -2309

Hydrophobicity -108.33

Aliphatic Index 25

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 11000

Absorbance 280nm 1000

Polar residues 3

Literature Information

Literature 1

Title Anti-dengue virus serotype 2 activity and mode of action of a novel peptide.

Pubmed ID 26248692

Reference J Appl Microbiol. 2015 Oct;119(4):1170-80.

Author Chew MF, Tham HW, Rajik M, Sharifah SH.

DOI 10.1111/jam.12921