General Information


DRAVP ID  DRAVPe00458

Peptide Name   P1

Sequence  CNDFRSKTC

Sequence Length  9

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  Influenza viruse

Assay 

Activity 

  • [Ref.19680476]Avian influenza viruses (AIV) H9N2: inhibition of viral attachment on MDCK cells(>50% inhibition at the concentration of 50 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  membrane

Mechanism  Avian influenza viruses possess two important surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA) against which neutralizing antibodies are produced. This peptide inhibits the replication of the virus in ovo and in vitro by its binding to the HA glycoprotein.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00458

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C42H68N14O15S2

Absent amino acids  AEGHILMPQVWY

Common amino acids  C

Mass  1073.21

Pl  8.06

Basic residues  2

Acidic residues  1

Hydrophobic residues  1

Net charge  1

Boman Index  -3626

Hydrophobicity  -101.11

Aliphatic Index  0

Half Life 

  •     Mammalian:1.2 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  125

Absorbance 280nm  15.63

Polar residues  5



Literature Information


Literature 1

Title   A novel peptide inhibits the influenza virus replication by preventing the viral attachment to the host cells. 

Pubmed ID   19680476

Reference   Int J Biol Sci. 2009 Aug 8;5(6):543-8.

Author   Rajik M, Omar AR, Ideris A, Hassan SS, Yusoff K.

DOI   10.7150/ijbs.5.543