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General Information
DRAVP ID DRAVPe00460
Peptide Name P1
Sequence TEPSTRGSWKFW
Sequence Length 12
UniProt ID No entry found
Source Synthetic construct(phage display)
Activity Information
Target Organism JEV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target envelope protein
Mechanism E glycoprotein has been identified as the major antigenic determinant on flavivirus particles and mediates binding and fusion during viral entry,DIII has been proposed to act as the binding region for the cellular receptor. And the peptide could bingding with DIII domain and inhibit the initial step of JEV infection.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00460
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C69H96N18O19
Absent amino acids ACDHILMNQVY
Common amino acids STW
Mass 1481.63
Pl 8.41
Basic residues 2
Acidic residues 1
Hydrophobic residues 3
Net charge 1
Boman Index -3064
Hydrophobicity -132.5
Aliphatic Index 0
Half Life
Extinction Coefficient cystines 11000
Absorbance 280nm 1000
Polar residues 5
Literature Information
Literature 1
Title Peptide inhibitor of Japanese encephalitis virus infection targeting envelope protein domain III.
Pubmed ID 24468276
Reference Antiviral Res. 2014 Apr;104:7-14.
Author Zu X, Liu Y, Wang S, Jin R, Zhou Z, Liu H, Gong R, Xiao G, Wang W.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.