DRAVP ID  DRAVPe00461

Peptide Name   P3

Sequence  SENRKVPFYSHS

Sequence Length  12

UniProt ID  No entry found

Source  Synthetic construct(phage display)

Target Organism  JEV

Assay 

Activity 

• [Ref.24468276]Japanese encephalitis virus (JEV): inhibition of JEV infection in BHK-21 cells(IC50=1.42 ± 0.41 μM determined by plaque assay,IC50=1.12 ± 0.38 μM determined by qRT-PCR,IC90~100 μM determined by plaque assay and qRT-PCR).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  envelope protein

Mechanism  E glycoprotein has been identified as the major antigenic determinant on flavivirus particles and mediates binding and fusion during viral entry,DIII has been proposed to act as the binding region for the cellular receptor. And the peptide could bingding with DIII domain and inhibit the initial step of JEV infection.

PDB ID  None

Predicted Structure Download  DRAVPe00461

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Peptide inhibitor of Japanese encephalitis virus infection targeting envelope protein domain III.

Pubmed ID   24468276

Reference   Antiviral Res. 2014 Apr;104:7-14.

Author   Zu X, Liu Y, Wang S, Jin R, Zhou Z, Liu H, Gong R, Xiao G, Wang W.

DOI   10.1016/j.antiviral.2014.01.011