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General Information
DRAVP ID DRAVPe00462
Peptide Name DN80
Sequence MVDRGWGNHAGLFGKGSIV
Sequence Length 19
UniProt ID No entry found
Source Synthetic construct(derived from the E polyprotein of DENV)
Activity Information
Target Organism DENV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target envelope
Mechanism The peptide may play roles in protein-protein rearrangements or bilayer membrane interactions during the entry and fusion process and thus inhibit infection of DENV or WNV.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00462
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C89H137N27O24S
Absent amino acids CEPQTY
Common amino acids G
Mass 2001.29
Pl 8.52
Basic residues 3
Acidic residues 1
Hydrophobic residues 7
Net charge 2
Boman Index -1180
Hydrophobicity 4.74
Aliphatic Index 76.84
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 305.56
Polar residues 7
Literature Information
Literature 1
Title Peptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses.
Pubmed ID 31351847
Reference Bioorg Med Chem. 2019 Sep 15;27(18):3963-3978.
Author da Silva-Júnior EF, de Araújo-Júnior JX.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.