General Information


DRAVP ID  DRAVPe00462

Peptide Name   DN80

Sequence  MVDRGWGNHAGLFGKGSIV

Sequence Length  19

UniProt ID  No entry found

Source  Synthetic construct(derived from the E polyprotein of DENV)



Activity Information


Target Organism  DENV

Assay 

Activity 

  • [Ref.31351847]Dengue virus(DENV): inhibition of DENV infection in LLCKM-2 monkey kidney epithelial cells(17±10% inhibition at 49.9 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  envelope

Mechanism  The peptide may play roles in protein-protein rearrangements or bilayer membrane interactions during the entry and fusion process and thus inhibit infection of DENV or WNV.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00462

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C89H137N27O24S

Absent amino acids  CEPQTY

Common amino acids  G

Mass  2001.29

Pl  8.52

Basic residues  3

Acidic residues  1

Hydrophobic residues  7

Net charge  2

Boman Index  -1180

Hydrophobicity  4.74

Aliphatic Index  76.84

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  305.56

Polar residues  7



Literature Information


Literature 1

Title   Peptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses.

Pubmed ID   31351847

Reference   Bioorg Med Chem. 2019 Sep 15;27(18):3963-3978. 

Author   da Silva-Júnior EF, de Araújo-Júnior JX. 

DOI   10.1016/j.bmc.2019.07.038