To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00463
Peptide Name DN57
Sequence AWLVHTQWFLDLPLPWLPGADTQGSNWI
Sequence Length 28
UniProt ID No entry found
Source Synthetic construct(derived from the E polyprotein of DENV)
Activity Information
Target Organism DENV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target envelope
Mechanism The peptide may play roles in protein-protein rearrangements or bilayer membrane interactions during the entry and fusion process and thus inhibit infection of DENV or WNV.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00463
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C158H221N37O39
Absent amino acids CEKMRY
Common amino acids L
Mass 3262.72
Pl 4.2
Basic residues 1
Acidic residues 2
Hydrophobic residues 14
Net charge -1
Boman Index 300
Hydrophobicity 7.14
Aliphatic Index 101.07
Half Life
Extinction Coefficient cystines 22000
Absorbance 280nm 814.81
Polar residues 6
Literature Information
Literature 1
Title Peptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses.
Pubmed ID 31351847
Reference Bioorg Med Chem. 2019 Sep 15;27(18):3963-3978.
Author da Silva-Júnior EF, de Araújo-Júnior JX.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.