To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00464
Peptide Name DN81
Sequence AWLVHRQWFLDLPLPWLPG
Sequence Length 19
UniProt ID No entry found
Source Synthetic construct(derived from the E polyprotein of DENV)
Activity Information
Target Organism DENV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target envelope
Mechanism The peptide may play roles in protein-protein rearrangements or bilayer membrane interactions during the entry and fusion process and thus inhibit infection of DENV or WNV.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00464
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C118H166N28O23
Absent amino acids CEIKMNSTY
Common amino acids L
Mass 2344.79
Pl 6.79
Basic residues 2
Acidic residues 1
Hydrophobic residues 11
Net charge 1
Boman Index 752
Hydrophobicity 27.37
Aliphatic Index 123.16
Half Life
Extinction Coefficient cystines 16500
Absorbance 280nm 916.67
Polar residues 1
Literature Information
Literature 1
Title Peptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses.
Pubmed ID 31351847
Reference Bioorg Med Chem. 2019 Sep 15;27(18):3963-3978.
Author da Silva-Júnior EF, de Araújo-Júnior JX.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.