DRAVP ID  DRAVPe00467

Peptide Name   WN53

Sequence  TFLVHREWFMDLNLPWSSAGSTVWR

Sequence Length  25

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct(derived from the E polyprotein of WNV)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  WNV

Assay 

Activity 

• [Ref.31351847]West Nile virus(WNV): inhibition of WNV infection in LLCKM-2 monkey kidney epithelial cells(IC50~10μM,56.0±3.0% inhibition at 99μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.31351847]No cytotoxicity against LLCMK-2 monkey kidney epithelial cells at 100 mg/ml.

Binding Target  envelope

Mechanism  The peptide may play roles in protein-protein rearrangements or bilayer membrane interactions during the entry and fusion process and thus inhibit infection of DENV or WNV.

PDB ID  None

Predicted Structure Download  DRAVPe00467

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Peptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses.

Pubmed ID   31351847

Reference   Bioorg Med Chem. 2019 Sep 15;27(18):3963-3978. 

Author   da Silva-Júnior EF, de Araújo-Júnior JX. 

DOI   10.1016/j.bmc.2019.07.038