To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00475
Peptide Name ACE2 (37-45)(SAP2)
Sequence EDLFYQSSL
Sequence Length 9
UniProt ID Q9BYF1
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism SARS-CoV-2
Assay pseudovirus inhibition assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not found
Mechanism Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00475
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C50H72N10O18
Absent amino acids ACGHIKMNPRTVW
Common amino acids LS
Mass 1101.18
Pl 3.67
Basic residues 0
Acidic residues 2
Hydrophobic residues 3
Net charge -2
Boman Index -1519
Hydrophobicity -33.33
Aliphatic Index 86.67
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 186.25
Polar residues 3
Literature Information
Literature 1
Title Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2.
Pubmed ID 33356169
Reference Bioconjug Chem. 2021 Jan 20;32(1):215-223.
Author Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.