To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00477
Peptide Name ACE2 (352-359)(SAP4)
Sequence GKGDFRIL
Sequence Length 8
UniProt ID Q9BYF1
Source Synthetic construct
Activity Information
Target Organism SARS-CoV-2
Assay pseudovirus inhibition assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not found
Mechanism Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00477
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C41H68N12O11
Absent amino acids ACEHMNPQSTVWY
Common amino acids G
Mass 905.06
Pl 8.75
Basic residues 2
Acidic residues 1
Hydrophobic residues 3
Net charge 1
Boman Index -1449
Hydrophobicity -20
Aliphatic Index 97.5
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2.
Pubmed ID 33356169
Reference Bioconjug Chem. 2021 Jan 20;32(1):215-223.
Author Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.