DRAVP ID  DRAVPe00479

Peptide Name   ACE2 (37-42)(SAP6)

Sequence  EDLFYQ

Sequence Length  6

UniProt ID  Q9BYF1 

Source  Synthetic construct

Target Organism  SARS-CoV-2,SARS-CoV,VSV

Assay  pseudovirus inhibition assay

Activity 

• [Ref.33356169]SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells(IC50=1.9±0.14 mM);Inhibition of infection in 293T/ACE2/GFP cells(IC50=3 mM);
• SARS-CoV:Inhibition of infection in 293T/ACE2 cells(85% inhibition at 3 mM);
• Vesicular Stomatitis Virus (VSV):No nhibition of infection in 293T/ACE2 cells up to 3 mM;
• HCoV-NL63:Inhibition of cytopathic effect in LLC-MK2 cells(30% Inhibition at 3 mM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors.

PDB ID  None

Predicted Structure Download  DRAVPe00479

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2.

Pubmed ID   33356169

Reference   Bioconjug Chem. 2021 Jan 20;32(1):215-223.

Author   Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A.

DOI   10.1021/acs.bioconjchem.0c00664