To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00516
Peptide Name MT-WQ-IDL-scrambled
Sequence EEQKTQLKNKIEIDWTKMELEQDWSKIYKEI
Sequence Length 31
UniProt ID P04578
Source Synthetic construct
Activity Information
Target Organism HIV
Assay ELISA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target membrane
Mechanism The peptide inhibits HIV fusion by binding to the hydrophobic grooves on the N-terminal heptad repeat (NHR) trimer and blocking six-helix-bundle (6-HB) formation.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00516
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C176H279N43O56S
Absent amino acids ACFGHPRV
Common amino acids EK
Mass 3925.47
Pl 4.86
Basic residues 6
Acidic residues 8
Hydrophobic residues 8
Net charge -2
Boman Index -8701
Hydrophobicity -139.35
Aliphatic Index 75.48
Half Life
Extinction Coefficient cystines 12490
Absorbance 280nm 416.33
Polar residues 5
Literature Information
Literature 1
Title Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors.
Pubmed ID 27795416
Reference J Virol. 2016 Dec 16;91(1):e01445-16.
Author Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.