DRAVP ID  DRAVPe00524

Peptide Name   peptide 7

Sequence  RILQQLLFIHFRIGRRRRRRRR

Sequence Length  22

UniProt ID  No entry found

Source  Synthetic construct

Target Organism  HIV

Assay  Integrase assay

Activity 

• [Ref.20708407]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=0.13 ± 0.02 µM);inhibition of strand transfer catalyzed by integrase(IC50=0.11 ± 0.01 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Integrase

Mechanism  The peptide acts antiviral activity by inhibiting the activity of integrase.

PDB ID  None

Predicted Structure Download  DRAVPe00524

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.

Pubmed ID   20708407

Reference   Bioorg Med Chem. 2010 Sep 15;18(18):6771-5.

Author   Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H.

DOI   10.1016/j.bmc.2010.07.050