General Information
DRAVP ID DRAVPe00525
Peptide Name peptide 8
Sequence IRILQQLLFIHFRIGRRRRRRRR
Sequence Length 23
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HIV
Assay Integrase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Integrase
Mechanism The peptide acts antiviral activity by inhibiting the activity of integrase.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00525
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C138H243N57O26
Absent amino acids ACDEKMNPSTVWY
Common amino acids R
Mass 3116.81
Pl 12.95
Basic residues 11
Acidic residues 0
Hydrophobic residues 9
Net charge 11
Boman Index -12360
Hydrophobicity -89.57
Aliphatic Index 118.7
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Literature Information
Literature 1
Title Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.
Pubmed ID 20708407
Reference Bioorg Med Chem. 2010 Sep 15;18(18):6771-5.
Author Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H.