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General Information
DRAVP ID DRAVPe00550
Peptide Name C16- N25
Sequence RQLLSGIVQQQNNLLRAIEAQQHLL
Sequence Length 25
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HIV
Assay cell-cell fusion inhibition assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism N peptide may target an exposed C-helix region of gp41 and can interact with their coiled coil formation within a gp41 dimer,which can inhibit HIV-1 entry.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00550
Linear/Cyclic Linear
N-terminal Modification C16(hexadecanoic acid)
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C125H215N41O37
Absent amino acids CDFKMPTWY
Common amino acids LQ
Mass 2884.33
Pl 9.61
Basic residues 3
Acidic residues 1
Hydrophobic residues 11
Net charge 2
Boman Index -4327
Hydrophobicity -21.2
Aliphatic Index 144.4
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Literature Information
Literature 1
Title Virus-cell and cell-cell fusion mediated by the HIV-1 envelope glycoprotein is inhibited by short gp41 N-terminal membrane-anchored peptides lacking the critical pocket domain.
Pubmed ID 20605950
Reference FASEB J. 2010 Nov;24(11):4196-202.
Author Wexler-Cohen Y, Ashkenazi A, Viard M, Blumenthal R, Shai Y.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.