To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00555
Peptide Name P21S4
Sequence LDLTXEMLXLQQVVKALNESY
Sequence Length 21
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism MERS-CoV
Assay Inhibition of MERS-CoV S-Protein-Mediated Cell–Cell Fusion Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide inhibits MERS-CoV infection and its spike (S) protein-mediated cell–cell fusion.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification ①The 'X' (position: 5 and 9) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (5) and X (9) are cross-linked by hydrocarbon stapling.
Stereochemistry L
Physicochemical Information
Formula C98H159N23O30S
Absent amino acids CFGHIPRW
Common amino acids L
Mass 2430.23
Pl 4.14
Basic residues 1
Acidic residues 3
Hydrophobic residues 8
Net charge -2
Boman Index -1488
Hydrophobicity 16.19
Aliphatic Index 125.24
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 74.5
Polar residues 4
Literature Information
Literature 1
Title Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors.
Pubmed ID 29442512
Reference J Med Chem. 2018 Mar 8;61(5):2018-2026.
Author Wang C, Xia S, Zhang P, Zhang T, Wang W, Tian Y, Meng G, Jiang S, Liu K.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.