General Information
DRAVP ID DRAVPe00556
Peptide Name P21S5
Sequence LDLTYEMXSLQXVVKALNESY
Sequence Length 21
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism MERS-CoV
Assay Inhibition of MERS-CoV S-Protein-Mediated Cell–Cell Fusion Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide inhibits MERS-CoV infection and its spike (S) protein-mediated cell–cell fusion.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification ①The 'X' (position: 8 and 12) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (8) and X (12) are cross-linked by hydrocarbon stapling.
Stereochemistry L
Physicochemical Information
Formula C99H154N22O31S
Absent amino acids CFGHIPRW
Common amino acids L
Mass 2439.19
Pl 4.14
Basic residues 1
Acidic residues 3
Hydrophobic residues 7
Net charge -2
Boman Index -1780
Hydrophobicity 4.76
Aliphatic Index 106.67
Half Life
Extinction Coefficient cystines 2980
Absorbance 280nm 149
Polar residues 6
Literature Information
Literature 1
Title Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors.
Pubmed ID 29442512
Reference J Med Chem. 2018 Mar 8;61(5):2018-2026.
Author Wang C, Xia S, Zhang P, Zhang T, Wang W, Tian Y, Meng G, Jiang S, Liu K.