To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00575
Peptide Name FP4(FCoV Sgp (1338-1380))
Sequence FNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTLVNL
Sequence Length 43
UniProt ID P10033
Source Synthetic construct(derived from S protein of FCoV)
Activity Information
Target Organism FCoV
Assay plaque reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide can interfere the fusion of the viral envelope with host membrane and thus inhibits viral replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00575
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C218H348N56O72
Absent amino acids CMPQW
Common amino acids L
Mass 4905.49
Pl 4.19
Basic residues 3
Acidic residues 7
Hydrophobic residues 18
Net charge -4
Boman Index -6376
Hydrophobicity -1.4
Aliphatic Index 126.98
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 35.48
Polar residues 15
Literature Information
Literature 1
Title Peptides corresponding to the predicted heptad repeat 2 domain of the feline coronavirus spike protein are potent inhibitors of viral infection.
Pubmed ID 24312629
Reference PLoS One. 2013 Dec 3;8(12):e82081.
Author Liu IJ, Tsai WT, Hsieh LE, Chueh LL.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.