To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00584
Peptide Name SC27EK
Sequence WEEWDKKIEEYTKKIEELIKKSEEQQK
Sequence Length 27
UniProt ID Q5DP94
Source Synthetic construct
Activity Information
Target Organism HIV
Assay dual split-protein (DSP)-based cell-cell fusion assay,luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide inhibits HIV fusion by binding to the hydrophobic grooves on the N-terminal heptad repeat (NHR) trimer and blocking six-helix-bundle (6-HB) formation.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00584
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C158H248N38O51
Absent amino acids ACFGHMNPRV
Common amino acids E
Mass 3495.93
Pl 4.97
Basic residues 7
Acidic residues 9
Hydrophobic residues 6
Net charge -2
Boman Index -9490
Hydrophobicity -196.67
Aliphatic Index 57.78
Half Life
Extinction Coefficient cystines 12490
Absorbance 280nm 480.38
Polar residues 3
Literature Information
Literature 1
Title Conserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors.
Pubmed ID 31277353
Reference Viruses. 2019 Jul 3;11(7):609.
Author Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.