To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00591
Peptide Name SC20EK
Sequence WEEWDKKIEEYTKKIEELIK
Sequence Length 20
UniProt ID Q5DP94
Source Synthetic construct
Activity Information
Target Organism HIV
Assay dual split-protein (DSP)-based cell-cell fusion assay,luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide inhibits HIV fusion by binding to the hydrophobic grooves on the N-terminal heptad repeat (NHR) trimer and blocking six-helix-bundle (6-HB) formation.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00591
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C123H189N27O37
Absent amino acids ACFGHMNPQRSV
Common amino acids E
Mass 2638.01
Pl 4.82
Basic residues 5
Acidic residues 7
Hydrophobic residues 6
Net charge -2
Boman Index -5570
Hydrophobicity -152.5
Aliphatic Index 78
Half Life
Extinction Coefficient cystines 12490
Absorbance 280nm 657.37
Polar residues 2
Literature Information
Literature 1
Title Conserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors.
Pubmed ID 31277353
Reference Viruses. 2019 Jul 3;11(7):609.
Author Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.