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General Information
DRAVP ID DRAVPe00627
Peptide Name peptide 4ef(derived from RSV fusion protein(497-515))
Sequence XKINQSLXFIRXSDELLHXV
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct(derived from RSV fusion protein)
Activity Information
Target Organism RSV
Assay rHRSV-mCherry inhibition assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism The peptide disrupts the formation of the postfusion six-helix bundle required for viral cell entry.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification Acetylation
C-terminal Modification Free
Other Modification The 'X' at position 1,8 indicates R-octenyl-alanine; The 'X' at position 12,19 indicates S-pentenylalanine, X(1) and X(8), X(12) and X(19) are cross-linked by hydrocarbon stapling.
Stereochemistry L
Physicochemical Information
Formula C86H134N24O21
Absent amino acids ACGMPTWY
Common amino acids X
Mass 2357.54
Pl 6.75
Basic residues 3
Acidic residues 2
Hydrophobic residues 7
Net charge 1
Boman Index -2802
Hydrophobicity 1
Aliphatic Index 112
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Literature Information
Literature 1
Title A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading.
Pubmed ID 28137809
Reference Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02241-16.
Author Gaillard V, Galloux M, Garcin D, Eléouët JF, Le Goffic R, Larcher T, Rameix-Welti MA, Boukadiri A, Héritier J, Segura JM, Baechler E, Arrell M, Mottet-Osman G, Nyanguile O.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.