DRAVP ID  DRAVPe00696

Peptide Name   Indolicidin (Cathelicidin-4)

Sequence  ILPWKWPWWPWRR

Sequence Length  13

UniProt ID  P33046  A3KN14 

Source  Bos taurus (Bovine)

Target Organism  HSV,HIV

Assay  HIV-1 integrase inhibition assay

Activity 

• [Ref.15081088]Herpes simplex virus type 1 (HSV-1):inhibition of HSV-1 infection in Vero cells(EC50=28.68 μM);
• Herpes simplex virus type 2 (HSV-2):inhibition of HSV-2 infection in Vero cells(EC50=5.00 μM).
• [Ref.15482931]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=60 µM);inhibition of strand transfer catalyzed by integrase(IC50=57 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.15081088]Vero cells:CC50>100 μM.

Binding Target  HIV Integrase

Mechanism  The HIV-1 integrase plays a crucial role in the HIV-1 virus replication cycle. The peptide can inhibit the activity of integrase and thus inhibit virus replication.

PDB ID  1G8C  1G89 

Predicted Structure Download  DRAVPe00696

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidtion

Other Modification  None

Stereochemistry  L

Literature 1

Title   Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus.

Pubmed ID   15081088

Reference    Int J Antimicrob Agents. 2004 Apr;23(4):382-9.

Author   Albiol Matanic VC, Castilla V.

DOI   10.1016/j.ijantimicag.2003.07.022

Literature 2

Title   Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.

Pubmed ID   15482931

Reference   Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8.

Author   Krajewski K, Marchand C, Long YQ, Pommier Y, Roller PP.

DOI   10.1016/j.bmcl.2004.08.061