DRAVP ID  DRAVPe00699

Peptide Name   Indolicidin (1-12)[R12P]

Sequence  ILPWKWPWWPWP

Sequence Length  12

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct(derived from Indolicidin)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HIV

Assay  HIV-1 integrase inhibition assay

Activity 

• [Ref.15482931]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=180 µM);inhibition of strand transfer catalyzed by integrase(IC50=80 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  HIV Integrase

Mechanism  The HIV-1 integrase plays a crucial role in the HIV-1 virus replication cycle. The peptide can inhibit the activity of integrase and thus inhibit virus replication.

PDB ID  None

Predicted Structure Download  DRAVPe00699

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidtion

Other Modification  None

Stereochemistry  L

Literature 1

Title   Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.

Pubmed ID   15482931

Reference   Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8.

Author   Krajewski K, Marchand C, Long YQ, Pommier Y, Roller PP. 

DOI   10.1016/j.bmcl.2004.08.061