DRAVP ID  DRAVPe00699

Peptide Name   Indolicidin (1-12)[R12P]

Sequence  ILPWKWPWWPWP

Sequence Length  12

UniProt ID  No entry found

Source  Synthetic construct(derived from Indolicidin)

Target Organism  HIV

Assay  HIV-1 integrase inhibition assay

Activity 

• [Ref.15482931]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=180 µM);inhibition of strand transfer catalyzed by integrase(IC50=80 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  HIV Integrase

Mechanism  The HIV-1 integrase plays a crucial role in the HIV-1 virus replication cycle. The peptide can inhibit the activity of integrase and thus inhibit virus replication.

PDB ID  None

Predicted Structure Download  DRAVPe00699

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidtion

Other Modification  None

Stereochemistry  L

Literature 1

Title   Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.

Pubmed ID   15482931

Reference   Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8.

Author   Krajewski K, Marchand C, Long YQ, Pommier Y, Roller PP. 

DOI   10.1016/j.bmcl.2004.08.061