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General Information
DRAVP ID DRAVPe00708
Peptide Name peptide derived from hydrolysate of oyster
Sequence LEYS
Sequence Length 4
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HIV
Assay HIV-1 protease inhibition assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target HIV-1 protease
Mechanism The HIV-1 protease is a virally encoded protease that serves to cleave the gag and gag-pol polyprotein precursor into mature, functional proteins. This specific proteolysis occurs late in the viral life cycle and is essential for the maturation of the infectious virus. The peptide inhibits HIV-1 protease and thus acts antiviral activity.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00708
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C23H34N4O9
Absent amino acids ACDFGHIKMNPQRTVW
Common amino acids ELSY
Mass 510.54
Pl 4
Basic residues 0
Acidic residues 1
Hydrophobic residues 1
Net charge -1
Boman Index -543
Hydrophobicity -45
Aliphatic Index 97.5
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 496.67
Polar residues 2
Literature Information
Literature 1
Title Isolation of HIV-1 protease-inhibiting peptides from thermolysin hydrolysate of oyster proteins.
Pubmed ID 9918775
Reference Biochem Biophys Res Commun. 1998 Dec 30;253(3):604-8.
Author Lee TG, Maruyama S.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.