To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00711
Peptide Name KM7
Sequence KPFVFLM
Sequence Length 7
UniProt ID No entry found
Source Synthetic construct(derived from the C-terminal sequence of α1-antitrypsin)
Activity Information
Target Organism HIV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism No machanism information found in the reference(s) presented in this entry
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00711
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C45H68N8O8S
Absent amino acids ACDEGHINQRSTWY
Common amino acids F
Mass 881.14
Pl 8.75
Basic residues 1
Acidic residues 0
Hydrophobic residues 4
Net charge 1
Boman Index 1172
Hydrophobicity 142.86
Aliphatic Index 97.14
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Literature Information
Literature 1
Title Short cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity.
Pubmed ID 22406118
Reference Bioorg Med Chem Lett. 2012 Apr 1;22(7):2393-5.
Author Jia Q, Jiang X, Yu F, Qiu J, Kang X, Cai L, Li L, Shi W, Liu S, Jiang S, Liu K.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.