To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe00713
Peptide Name PI6
Sequence PFVYLI
Sequence Length 6
UniProt ID No entry found
Source Synthetic construct(derived from the C-terminal sequence of α1-antitrypsin)
Activity Information
Target Organism HIV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism No machanism information found in the reference(s) presented in this entry
Structure Information
PDB ID None
Predicted Structure Download DRAVPe00713
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C40H58N6O8
Absent amino acids ACDEGHKMNQRSTW
Common amino acids FILPVY
Mass 750.94
Pl 5.95
Basic residues 0
Acidic residues 0
Hydrophobic residues 4
Net charge 0
Boman Index 1672
Hydrophobicity 206.67
Aliphatic Index 178.33
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 298
Polar residues 1
Literature Information
Literature 1
Title Short cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity.
Pubmed ID 22406118
Reference Bioorg Med Chem Lett. 2012 Apr 1;22(7):2393-5.
Author Jia Q, Jiang X, Yu F, Qiu J, Kang X, Cai L, Li L, Shi W, Liu S, Jiang S, Liu K.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.