General Information


DRAVP ID  DRAVPe00722

Peptide Name   T1562(FIV envelope protein (724-758))

Sequence  IWNHGNITLGEWYNQTKDLQQKFYEIIMDIEQNNV

Sequence Length  35

UniProt ID  P16090 

Source  Synthetic construct(derived from FIV envelope protein)



Activity Information


Target Organism  FIV

Assay  plaque-forming assay,RT infectivity assay

Activity 

  • [Ref.12186891]Feline immunodeficiency virus (FIV):inhibition of cell-cell fusion between FIV/CrFK cells and HeLa cells(EC50=0.318 μM,EC90=1.236 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00722

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C194H288N50O59S

Absent amino acids  ACPRS

Common amino acids  IN

Mass  4296.78

Pl  4.5

Basic residues  3

Acidic residues  5

Hydrophobic residues  11

Net charge  -2

Boman Index  -6406

Hydrophobicity  -78.86

Aliphatic Index  86.29

Half Life 

  •     Mammalian:20 hour
  •     Yeast:30 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  13980

Absorbance 280nm  411.18

Polar residues  11



Literature Information


Literature 1

Title   C-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. 

Pubmed ID   12186891

Reference   J Virol. 2002 Sep;76(18):9079-86.

Author   Medinas RJ, Lambert DM, Tompkins WA.

DOI   10.1128/jvi.76.18.9079-9086.2002