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General Information
DRAVP ID DRAVPe00739
Peptide Name SAH-gp41(626-662) B
Sequence XTWMEWDREINNYTSLIHSLIEESQNQXEKNXQELLE
Sequence Length 37
UniProt ID P04582
Source Synthetic construct
Activity Information
Target Organism HIV
Assay luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism The peptide disrupts assembly of the six-helix bundle viral fusion apparatus by mimicking the heptad repeat 2 (HR2) oligomerization domain of the gp41 envelope glycoprotein.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Free
Other Modification The 'X' at position 1 indicates Norleucine,the 'X' at position 28,32 indicates S-2-(4'-pentenyl) alanine. X(28) and X (32) are cross-linked by hydrocarbon stapling.
Stereochemistry L
Physicochemical Information
Formula C183H273N49O61S
Absent amino acids ACFGPV
Common amino acids E
Mass 4555.57
Pl 4.21
Basic residues 3
Acidic residues 8
Hydrophobic residues 9
Net charge -5
Boman Index -9873
Hydrophobicity -109.19
Aliphatic Index 73.78
Half Life
Extinction Coefficient cystines 12490
Absorbance 280nm 346.94
Polar residues 10
Literature Information
Literature 1
Title Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.
Pubmed ID 20660316
Reference Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14093-8.
Author Bird GH, Madani N, Perry AF, Princiotto AM, Supko JG, He X, Gavathiotis E, Sodroski JG, Walensky LD.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.