DRAVP ID  DRAVPe00753

Peptide Name   Eval418

Sequence  LWGEIWNTVKGLI

Sequence Length  13

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  HSV

Assay  Antiviral assays

Activity 

• [Ref.29290802]HSV-1:inhibition of viral inactivation in Vero cells(IC50=2.48 μg/ml);inhibition of viral attachment in Vero cells(IC50=3.70 μg/ml);inhibition of viral entry in Vero cells(IC50=31.71 μg/ml).

Hemolytic Activity 

• [Ref.29290802]the cell viability of erythrocytes was also more than 95% at concentrations of Eval418 of 10 μg/mL or less.

Cytotoxicity 

• [Ref.29290802]Vero cell:CC50=68.50μg/mL; the cell viability of the peptide-treated Vero cells was greater than 95% after treatment with Eval418 at 10 μg/mL.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  DRAVPe00753

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1.

Pubmed ID   29290802

Reference   Theranostics. 2018 Jan 1;8(1):199-211.

Author   Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z.

DOI   10.7150/thno.21425