DRAVP ID  DRAVPe00761

Peptide Name   IN(1-10)[C3S]

Sequence  WQSLTLTHRG

Sequence Length  10

UniProt ID  No entry found

Source  Synthetic construct

Target Organism  HIV

Assay  MAGI assay

Activity 

• [Ref.19850483]HIV-1:inhibition of integrase catalytic activity(62% inhibition at 62.5μM);inhibition of virus replication in TZM-bl cells(60% inhibition at 62.5μM);inhibition of intergration(51% inhibition at 62.5μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Integrase

Mechanism  The peptide can inhibit integrase and thus inhibit virus replication.

PDB ID  None

Predicted Structure Download  DRAVPe00761

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Peptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds.

Pubmed ID   19850483

Reference   Bioorg Med Chem. 2009 Nov 15;17(22):7635-42.

Author   Maes M, Levin A, Hayouka Z, Shalev DE, Loyter A, Friedler A. 

DOI   10.1016/j.bmc.2009.09.053