DRAVP ID  DRAVPe00836

Peptide Name   Cecropin A

Sequence  GGLKKLGKKLEGAGKRVFNAAEKALPVVAGAKAL

Sequence Length  34

UniProt ID  P01508 

Source  Aedes aegypti (Yellowfever mosquito)

Target Organism  Tacaribe virus,JV,PICV

Assay 

Activity 

• [Ref.15081088]Junin virus(JV):inhibtion of JV infection in Vero cells(EC50=3.4 μM,EC90=28.57 μM);
• Tacaribe virus:inhibition of tacaribe virus infection in Vero cells(IC50=1.96 μM,EC90=33.39 μM);
• Pichinde virus:inhibition of Pichinde virus infection in Vero cells(IC50=6.56 μM,EC90=39 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.15081088]Vero cells:CC50>100 μM.

Binding Target  glycoprotein G1

Mechanism  Cecropin A caused an altered intracellular distribution and membrane expression of the viral glycoprotein G1, as it was shown by membrane and cytoplasmic IF assays,which indicate that the inhibition of G1 transport and/or insertion into the cell membrane might prevent the formation of infectious particles leading to the reduction of cell-associated infectivity.

PDB ID  2MMM 

Predicted Structure Download  DRAVPe00836

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidtion

Other Modification  None

Stereochemistry  L

Literature 1

Title   Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. 

Pubmed ID   15081088

Reference    Int J Antimicrob Agents. 2004 Apr;23(4):382-9.

Author   Albiol Matanic VC, Castilla V. 

DOI   10.1016/j.ijantimicag.2003.07.022