General Information
DRAVP ID DRAVPe00836
Peptide Name Cecropin A
Sequence GGLKKLGKKLEGAGKRVFNAAEKALPVVAGAKAL
Sequence Length 34
UniProt ID P01508
Source Aedes aegypti (Yellowfever mosquito)
Activity Information
Target Organism Tacaribe virus,JV,PICV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target glycoprotein G1
Mechanism Cecropin A caused an altered intracellular distribution and membrane expression of the viral glycoprotein G1, as it was shown by membrane and cytoplasmic IF assays,which indicate that the inhibition of G1 transport and/or insertion into the cell membrane might prevent the formation of infectious particles leading to the reduction of cell-associated infectivity.
Structure Information
PDB ID 2MMM
Predicted Structure Download DRAVPe00836
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidtion
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C154H269N45O40
Absent amino acids CDHIMQSTWY
Common amino acids AK
Mass 3391.11
Pl 10.39
Basic residues 8
Acidic residues 2
Hydrophobic residues 16
Net charge 6
Boman Index -1602
Hydrophobicity 2.06
Aliphatic Index 103.53
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 7
Literature Information
Literature 1
Title Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus.
Pubmed ID 15081088
Reference Int J Antimicrob Agents. 2004 Apr;23(4):382-9.
Author Albiol Matanic VC, Castilla V.