General Information


DRAVP ID  DRAVPe00841

Peptide Name   4(derived from FIV envelope glycoprotein )

Sequence  LKAKTNISIREGPTLGNWAR

Sequence Length  20

UniProt ID  P16090 

Source  Synthetic construct(derived from FIV envelope glycoprotein (gE))



Activity Information


Target Organism  FIV

Assay  Syncitia assay

Activity 

  • [Ref.8661378]Feline immunodeficiency virus (FIV):inhibition of virus replication in Crandell feline kidney (CrFK) fibroblastoid cells(24% inhibition at 16 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Syncytium formation

Mechanism  The machanism might be peptide bound the surface of FIV permissive cells and were highly active in blocking FIV infection when administered before the virus.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00841

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C98H165N31O28

Absent amino acids  CDFHMQVY

Common amino acids  AGIKLNRT

Mass  2225.58

Pl  11

Basic residues  4

Acidic residues  1

Hydrophobic residues  7

Net charge  3

Boman Index  -4206

Hydrophobicity  -63

Aliphatic Index  88

Half Life 

  •     Mammalian:5.5 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  5500

Absorbance 280nm  289.47

Polar residues  7



Literature Information


Literature 1

Title   Inhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides.

Pubmed ID   8661378

Reference   Virology. 1996 Jun 15;220(2):274-84. 

Author   Lombardi S, Massi C, Indino E, La Rosa C, Mazzetti P, Falcone ML, Rovero P, Fissi A, Pieroni O, Bandecchi P, Esposito F, Tozzini F, Bendinelli M, Garzelli C.

DOI   10.1006/viro.1996.0315