General Information


DRAVP ID  DRAVPe00850

Peptide Name   16(derived from FIV envelope glycoprotein )

Sequence  PNQTCMWNTSQIQDPEIPKC

Sequence Length  20

UniProt ID  P16090 

Source  Synthetic construct(derived from FIV envelope glycoprotein (gE))



Activity Information


Target Organism  FIV

Assay  Syncitia assay

Activity 

  • [Ref.8661378]Feline immunodeficiency virus (FIV):inhibition of virus replication in Crandell feline kidney (CrFK) fibroblastoid cells(5% inhibition at 16 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Syncytium formation

Mechanism  The machanism might be peptide bound the surface of FIV permissive cells and were highly active in blocking FIV infection when administered before the virus.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe00850

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C98H153N27O33S3

Absent amino acids  AFGHLRVY

Common amino acids  PQ

Mass  2333.63

Pl  4.37

Basic residues  1

Acidic residues  2

Hydrophobic residues  3

Net charge  -1

Boman Index  -4244

Hydrophobicity  -102

Aliphatic Index  39

Half Life 

  •     Mammalian:>20 hour
  •     Yeast:>20 hour
  •     E.coli:?

Extinction Coefficient cystines  5625

Absorbance 280nm  296.05

Polar residues  7



Literature Information


Literature 1

Title   Inhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides.

Pubmed ID   8661378

Reference   Virology. 1996 Jun 15;220(2):274-84. 

Author   Lombardi S, Massi C, Indino E, La Rosa C, Mazzetti P, Falcone ML, Rovero P, Fissi A, Pieroni O, Bandecchi P, Esposito F, Tozzini F, Bendinelli M, Garzelli C.

DOI   10.1006/viro.1996.0315