General Information

General Information

DRAVP ID DRAVPe00911

Peptide Name T-118

Sequence FDASISQVNEKINQSLAFIRKSDELLHNVNAGKST

Sequence Length 35

UniProt ID P69353

Source Synthetic construct(derived from Respiratory syncytial virus(RSV) fusion (F) protein)

Other Link DRAVPa1144

Activity Information

Target Organism RSV,HPIV,MeV

Assay Cytopathic effect(CPE) assay,antifusion assay,plaque reduction assay

Activity

[Ref.8700906]Respiratory syncytial virus(RSV):protection of HEp2 cell from viral cytopathic effect(CPE)(EC50=6 μg/ml);inhibition of cell-cell fusion in HEp2 cell(EC50=0.051 μg/ml);
measles virus(MV):inhibition of cell-cell fusion in HEp2 cell(EC50>25 μg/ml);
Human parainfluenza virus type 3(HPIV3):inhibition of cell-cell fusion in HEp2 cell(EC50>25 μg/ml);
HIV-1 LAI:inhibition of cell-cell fusion in HEp2 cell(EC50>50 μg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.8700906]No significant cytotoxic against HEp2 cells(CC50>100 μM).

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe00911

Linear/Cyclic Linear

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C168H273N49O56

Absent amino acids CMPWY

Common amino acids S

Mass 3875.31

Pl 6.76

Basic residues 5

Acidic residues 4

Hydrophobic residues 13

Net charge 1

Boman Index -7457

Hydrophobicity -43.43

Aliphatic Index 92

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 11

Literature Information

Literature 1

Title Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion.

Pubmed ID 8700906

Reference Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2186-91.

Author Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr.

DOI 10.1073/pnas.93.5.2186