General Information
DRAVP ID DRAVPe00930
Peptide Name HPIV3 F HRC derived peptide(454-488)
Sequence IDISIELNKAKSDLEESKEWIRRSNQKLDSIGNWH
Sequence Length 35
UniProt ID P06828
Source Synthetic construct(derived from HPIV3 fusion (F) protein)
Activity Information
Target Organism HeV,HPIV-3
Assay Luminescence fusion assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target membrane
Mechanism The HeV receptor-binding protein (G) is required in order for the fusion protein (F) to mediate fusion. HeV F, once triggered by the receptor-bound G, undergoes multistep conformational changes leading to a six-helix bundle (6HB) structure that accomplishes fusion of the viral and cellular membranes. Peptides derived from the HRN and HRC regions of F are proposed to inhibit fusion by preventing F, after the initial triggering step, from forming the 10HB structure that is required for fusion.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C181H291N53O59
Absent amino acids CFMPTVY
Common amino acids IS
Mass 4153.62
Pl 5.64
Basic residues 7
Acidic residues 7
Hydrophobic residues 11
Net charge 0
Boman Index -10579
Hydrophobicity -105.14
Aliphatic Index 92
Half Life
Extinction Coefficient cystines 11000
Absorbance 280nm 323.53
Polar residues 9
Literature Information
Literature 1
Title Inhibition of hendra virus fusion.
Pubmed ID 16973588
Reference J Virol. 2006 Oct;80(19):9837-49.
Author Porotto M, Doctor L, Carta P, Fornabaio M, Greengard O, Kellogg GE, Moscona A.