DRAVP ID  DRAVPe00941

Peptide Name   T-257

Sequence  LHRIDLGPPISLERLDVGTNLGNAIAKLEDAKELL

Sequence Length  35

UniProt ID  P69353 

Taxon ID  None

Source  Synthetic construct(derived from measles virus(MV) fusion (F) protein)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  MeV,RSV,HPIV-3,HIV

Assay  Cytopathic effect(CPE) assay,antifusion assay,plaque reduction assay

Activity 

• [Ref.8700906]measles virus(MeV):protection of HEp2 cell from viral cytopathic effect(CPE)(EC50=1.5 μg/ml);inhibition of cell-cell fusion in HEp2 cell(EC50=0.068 μg/ml);
• Human parainfluenza virus type 3(HPIV-3):inhibition of cell-cell fusion in HEp2 cell(EC50>25 μg/ml);
• Respiratory syncytial virus(RSV):inhibition of cell-cell fusion in HEp2 cell(EC50>25 μg/ml);
• HIV-1 LAI:inhibition of cell-cell fusion in HEp2 cell(EC50>50 μg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.8700906]No significant cytotoxic against HEp2 cells(CC50>100 μM).

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  DRAVPe00941

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. 

Pubmed ID   8700906

Reference   Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2186-91.

Author   Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr.

DOI   10.1073/pnas.93.5.2186