To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01087
Peptide Name 12(derived from HCV C5A)
Sequence WICEVLSDFK
Sequence Length 10
UniProt ID P26664
Source Synthetic construct(derived from HCV non-structural protein 5A)
Activity Information
Target Organism HCV
Assay RT-QPCR assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target membrane
Mechanism The peptide destabilizes viral structural integrity and has viral membranolytic activity.It interacts with the viral membrane to disrupt its integrity, release viral capsids, and expose the viral genome to exonucleases for degradation.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01087
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C58H86N12O16S
Absent amino acids AGHMNPQRTY
Common amino acids CDEFIKLSVW
Mass 1239.45
Pl 4.37
Basic residues 1
Acidic residues 2
Hydrophobic residues 5
Net charge -1
Boman Index -401
Hydrophobicity 52
Aliphatic Index 107
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 611.11
Polar residues 2
Literature Information
Literature 1
Title A virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro.
Pubmed ID 18287023
Reference Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-93.
Author Cheng G, Montero A, Gastaminza P, Whitten-Bauer C, Wieland SF, Isogawa M, Fredericksen B, Selvarajah S, Gallay PA, Ghadiri MR, Chisari FV.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.