General Information

General Information

DRAVP ID DRAVPe01131

Peptide Name gB94(496-510)

Sequence KTTSSIEFARLQFTY

Sequence Length 15

UniProt ID P06437

Source Synthetic construct(derived from HSV-1 B glycoprotein (gB))

Activity Information

Target Organism HSV

Assay beta-galactosidase activity(Comprehensive antiviral assay,Virus inactivation assay,cell protection assay,entry assay,attachment assay)

Activity

[Ref.19104014]Herpes simplex virus type 1(HSV-1):comprehensive antiviral activity(EC50=6.5±1.3 µM);inhibition of virus entry in Vero cells(EC50>200 µM);inhibition of virus infection in Vero cells(EC50=165.0±71.9 µM);ability of inactive virus(EC50=125±11.4 µM);inhibition of virus attachment on Vero cells(EC50>200 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.19104014]Not cytotoxic for Vero cells up to 200 µM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01131

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C82H126N20O25

Absent amino acids CDGHMNPVW

Common amino acids T

Mass 1792.02

Pl 8.59

Basic residues 2

Acidic residues 1

Hydrophobic residues 5

Net charge 1

Boman Index -2986

Hydrophobicity -31.33

Aliphatic Index 58.67

Half Life

Mammalian:1.3 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 1490

Absorbance 280nm 106.43

Polar residues 6

Literature Information

Literature 1

Title Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.

Pubmed ID 19104014

Reference Antimicrob Agents Chemother. 2009 Mar;53(3):987-96.

Author Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR.

DOI 10.1128/AAC.00793-08